Join the Mount Sinai Health System as a Post Doctoral Fellow and engage in groundbreaking research on Hippo pathway signaling in podocyte injury and glomerular disease. Located in the vibrant city of New York, this role offers a unique opportunity to contribute to innovative scientific advancements while being part of a prestigious academic medical system.
Details of Research Project: Title: Hippo pathway signaling in podocyte injury and glomerular disease. Our lab has identified Hippo pathway upstream regulator KIBRA (Kidney BRAin) protein as a novel mediator of podocyte injury via inhibition of downstream pro-survival transcriptional co-activator YAP. Our previous work has demonstrated that upregulated KIBRA podocyte expression increases susceptibility to a murine model of FSGS and also that WWC1 (the gene encoding KIBRA) is a risk gene for glomerular disease progression in human podocytopathies. Preliminary data suggests that increased KIBRA/Hippo pathway activation enhances podocyte injury in a diabetic milieu. We aim to test this hypothesis and the potential therapeutic role of small molecule Hippo mediators using complementary models including immortalized podocytes, hIPSC-derived podocytes and kidney organoids, diabetic rodent models, and banked human kidney tissue/biosamples. Other aims of this work include defining positive and negative regulators of WWC1/KIBRA expression and downstream consequences of increased Hippo pathway activity on key podocyte cytostructural elements, namely the actin cytoskeleton and focal adhesion complexes.
Responsibilities:
Qualifications:
Compensation: The salary range for the role is $72,500 - $80,000 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need.
Experience in laboratory research with a focus on molecular biology techniques.
Collaborative environment with opportunities to lead and mentor junior lab members.
Research focused on podocyte injury and glomerular disease.
Utilization of advanced microscopy techniques and molecular biology protocols.
Part of the Mount Sinai Health System, one of the largest academic medical systems in the New York metro area.
Engagement in multiple research projects with potential for significant publication output.
Full-time commitment with flexible hours based on research needs.
Mount Sinai Health System is dedicated to fostering an inclusive and collaborative workplace where all employees feel valued and empowered. The organization emphasizes continuous learning and innovation, striving to improve patient care and workplace experiences. Join a team that is committed to excellence and making a meaningful impact in healthcare.
New York City offers a dynamic lifestyle with a rich cultural scene, diverse neighborhoods, and endless opportunities for entertainment and dining. The city is known for its excellent schools, vibrant arts community, and numerous outdoor activities in nearby parks.
Mount Sinai Health Systems
New York, New York